Adult-type Granulosa Cell Ovarian Tumor: Clinicopathological Features, Outcomes and Prognostic factors

Amornrat Temtanakitpaisan, Pilaiwan Kleebkaow, Apiwat Aue-aungkul

Abstract


Objective: To evaluate the clinicopathological features, outcomes and prognostic factors affecting the disease-free interval in women with adult-type granulosa cell tumor.                                                                                                             Methods: A retrospective descriptive study of patients with adult-type granulosa cell tumors of the ovary (AGCTs) during January 2001 to October 2016 were recruited. The data record of all patients was analyzed to determine clinic-pathological features, treatment, survival and prognostic factors.

Results: Eighteen women with adult-type granulosa cell tumors (AGCTs) were diagnosed. The mean age+ SD was 48.72+ 5.95 years. The adnexal mass was the most common presenting symptoms (83.3%) and most were diagnosed in FIGO stage I (83.3%). The majority of patients (55.6 %) were treated with complete staging surgery. Additionally, 22.2% were given postoperative chemotherapy. Endometrial cancer was detected in only one case. The mean follow-up period+ SD was 43.11+ 26.02 months. No recurrence of disease was observed in all patients. The estimated 5-year disease-free survival (DFS) was 95% regardless of the stage of the disease. The stage disease slightly influenced disease-free survival. However, no statistical difference between stages (p=0.52). No prognostic factors associated with DFS significantly.

Conclusion: The majority of the patients with adult-type granulosa cell tumors of the ovary (AGCTs) presented in the early stage of disease and have excellent survival rate. Tumor removal procedure with or without complete staging surgery seemed to be the appropriate treatment for granulosa cell tumors. No prognostic factors affecting on disease-free survival rate was found.


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DOI (PDF (FULL TEXT)): http://dx.doi.org/10.31557/APJCC.2019.4.2.33

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