Survival outcomes in male breast cancer – A single institution experience

Nisha Hariharan

Abstract


ABSTRACT

Introduction

Male breast cancer is an uncommon entity. Due to the scarce numbers, treatment protocols have largely been extrapolated from available evidence for female breast cancers.

Methods

We analysed the clinicopathological features and survival outcomes for male breast cancer patients treated at our institute between January 2010 and June 2016.

Results

Of the 5534 women treated at our institute, we screened 40 male breast cancers of whom 33 had available follow up data and were included in the present analysis. Male breast cancer constituted 0.7% of all breast cancers. The median age was 60 years and the median tumor size was 3cm with 66% of patients having nodal disease at presentation. Invasive ductal carcinoma was the most common histology and 97% were hormone receptor positive.

Most of the patients (87.8%) underwent an upfront modified radical mastectomy. With a median follow up of 36 months, 10 patients experienced recurrences all of which were distant metastasis ((3 to the bone, 1 to the brain, and 6 had visceral metastasis). Of these, 7 patients succumbed to the disease. The 3-year overall survival was 78.7 %.

Conclusion

Male breast cancer is a rare clinical entity and current treatment guidelines follow those for women. Due to the lack of awareness, men often present to clinics at an advanced stage. Social support targeted at improving awareness and access to treatment could improve outcomes in this cohort.

Keywords

Male breast cancer, survival

 

 

 


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References


REFERENCES

Ian S Fentiman, Alain Fourquet, Gabriel N Hortobagyi, Male breast cancer, The Lancet, Volume 367, Issue 9510, 2006, Pages 595-604, ISSN 0140-6736, http://dx.doi.org/10.1016/S0140-6736(06)68226-3.

Siegel, R. L., Miller, K. D. and Jemal, A. (2016), Cancer statistics, 2016. CA: A Cancer Journal for Clinicians, 66: 7–30. doi:10.3322/caac.21332

Giordano, S. H., Cohen, D. S., Buzdar, A. U., Perkins, G. and Hortobagyi, G. N. (2004), Breast carcinoma in men. Cancer, 101: 51–57. doi:10.1002/cncr.20312

Gogia A, Raina V, Deo S, Shukla N K, Mohanti B K. Male breast cancer: A single institute experience. Indian J Cancer 2015;52:526-9

Rai, B. et al. “Breast cancer in males: a PGIMER experience.” Journal of cancer research and therapeutics 1 1 (2005): 31-3.

Shah S, Bhattacharyya S, Gupta A, Ghosh A, Basak S. Male breast cancer: a clinicopathological study of 42 patients in eastern India. Indian journal of surgical oncology. 2012;3(3):245-9

Ram D, K R Suhas, Selvakumar V P , Shukla H, Goel A, Kumar R & Kumar K. (2017). Male breast cancer: A retrospective review of clinical profile from a tertiary cancer care center of India. South Asian Journal of Cancer. 6. 141. 10.4103/sajc.sajc_2_17.

Leone, J.P, Zwenger, A.O, Iturbe, J. Et al Prognostic factors in male breast cancer: a population-based study. Breast Cancer Res Treat (2016) 156: 539 https://doi.org/10.1007/s10549-016-3768-1

Shukla NK, Seenu V, Goel AK, Raina V, Rath GK, Singh R, et al. Male breast cancer: A retrospective study from a regional cancer center in Northern India. J Surg Oncol 1996;61:143-8

Oger AS, Boukerrou M, Cutuli B, Campion L, Rousseau E, Bussières E, Raro P, Classe JM. Male breast cancer: prognostic factors, diagnosis and treatment: a multi-institutional survey of 95 cases. Gynecol Obstet Fertil. 2015 Apr;43(4) 290-296. doi:10.1016/j.gyobfe.2015.02.010. PMID: 25818033.




DOI (PDF (FULL TEXT)): http://dx.doi.org/10.22034/APJCC.2018.3.4.1

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Asia Pacific Organization for Cancer Prevention 

West Asia Organization for Cancer Prevention