Clinical Findings and Demography of Retinoblastoma in a Tertiary Hospital in a Remote Area in a Developing Country

Golda A M Simanjuntak, Gilbert W S Simanjuntak

Abstract


Purpose     :   To report clinical characteristics and demography of retinoblastoma managed in a tertiary eye hospital in a remote area in a developing country.

Methods   :   This is a descriptive retrospective study. Clinical characteristics were gender,   age, tumor growth, onset, severity, laterality, nutritional status, and prominent clinical signs. The socioeconomic demographics of the patient’s families were grouped into work and economic conditions, and education. Management and its outcome were recorded.

 Results    :   There were 91 samples, distributed evenly in five years. The frequency was even between middle income 45 patients (49.5%) and lower middle income 46 patients (50.5%). The mean age at diagnosis was 3-5 year with  49 patients (53,8%), ranging from 1 to 12 years. Male to female ratio was 1:1. Less nutritional status were 64 patients (70.3%). All cases occurred unilaterally without family history of RB, and laterality was equal between right and left eye, with 1:1 ratio. Those patients who mainly presented with extra ocular involvement  numbered  73 patients (80.2%)  and those with clinical symptoms of protruded numbered 70 patients (76.9%). Patients generally presented in stage IV of 70 cases (76.9%). The mean onset was 1-2 years in 43 cases (47.2%). The therapeutic management was chemotherapy. After treatment, all patients followed up  in two weeks.

Conclusion : RB patients referred to a tertiary hospitalin a remote area are more likely to come in advanced stage, from middle-income group parents.  More extraocular cases seen with major clinical features of  protruded eye with an onset of 2-3 years.


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References


Aerts I, Lumbroso-Le Rouic L, Gauthier-Villars M, Brisse H, Doz F, et al (2006) Retinoblastoma. Orphanet J Rare Dis,1, 1750-2.

Ali J, Honavar SG, Reddy VAP (2011). Orbital retinoblastoma: Present status and future challengers – A review. Saudi J Ophthalmol,25,159-7.

Ahmad A, Khan FS, Shamim W, Hanif A, Rodriguez-Galindo C (2016). Retinoblastoma-Clinical Spectrum and Treatment Outcome in Children. J of Rawalpindi Med Coll,20,198-1.

Corrêa ZM, Berry JL (2016). Retinoblastoma. American Academy of Ophthalmology. Availaible from: https://www.aao.org/pediatric-center-detail/retinoblastoma-2016 [Accessed 30 Juli 2017].

Dharmawidiarini D, Prijanto, Soebagjo HD (2010). Ocular Survival Rate Penderita Retinoblastoma yang Telah Dilakukan Enukleasi atau Eksenterasi di RSUD Dr. Soetomo Surabaya. J Oftalmol Indonesia.,7,94-2.

Dimaras H, Kimani K, Dimba E, Gronsdahi P, White A, et al,. (2012) Retinoblastoma. The Lancet, 379:1436-6

Ghassemi F, Chams H, Sabour S, Karkhaneh R, Farzbod F, et al. (2014) Characteristic of Germline and Non-germline Retinoblastomas. J Ophthalmic Vis Res, 9,188-4.

Kaiser PK, Scott IU, O’brien JM, Murray TG (2017) Retinoblastoma. Available from:http://www.djo.harvard.edu/site.php?url=/patients/pi/436. 2014 [Accessed 30 Juli].

Luo C, Deng YP(2013).Retinoblastoma: concerning its initiation and treatment. Int J Ophthalmol,6,397-1.

Meel R, Radhakrishnan V, Bakhshi S (2012). Current therapy and recent advances in the management of retinoblastoma. Indian J Med Paediatr Oncol,33,80-8.

Mallipatna A, Marino M, Singh AD(2016). Genetics of Retinoblastoma. Asia Pac J of Ophthalmol , 5, 260-4.

Mattosinho CCS, Grigorovski N, Lucena E, Ferman S, Soares de Moura ATM, et al. (2016) .Prediagnostic Intervals in Retinoblastoma: Experience at an Oncology Center in Brazil. J Glob Oncol.,3, 323-0

Naseripour M (2012). Retinoblastoma survival disparity: The expanding horizon in developing countries. Saudi J Ophthalmol,26,157-1.

Othman IS (2012). Retinoblastoma major review with updates on Middle East management protocols. Saudi J Ophthalmol,2,63-5.

Pandey AN (2014 ). Retinoblastoma: An overview. Saudi J Ophthalmol,4:310-5.

Soebagjo HD, Prastyani R, Sujuti H, Lyrawati D, Sumitro SB(2013). Profile of Retinoblastoma in East Java, Indonesia. World J of Med and Medical Sci Res.,1,51-6.

Tazi I, Hidane Z, Zafad S, Harif M, Benchekroun S, Ribeiro R (2008). Nutritional Status at Diagnosis of Children with Malignancies in Casablanca. Pediatr Blood Cancer, 51,495-8.

World Health Organization (2014).Retinoblastoma. In: Union for International Cancer Control 2014. Review of Cancer Medicines on the WHO List of Essential Medicines.pp 1-10.

World Health Organization (2014). Vision 2020 The Right to Sight. International Agency for the Prevention of Blindness,p1-10

Zimmermann K, Ammann RA, Kuehni C, Geest SD,Cignacoo E (2012). Malnutrition in pediatric patients with cancer at diagnosis and throughout therapy: A multicenter cohort study. Pediatr Blood Cancer,60,642-9.




DOI (PDF (FULL TEXT)): http://dx.doi.org/10.22034/APJCC.2018.3.2.17

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